Her2-Negative Breast Cancer – Epidemiology Forecast to 2028

Breast cancer is a malignant tumor that originates in the breast tissue. Most breast cancers are invasive tumors that have grown beyond the ducts or lobules of the breast and can metastasize to other parts of the body through the bloodstream and the lymphatic system. HER2-/HR+ breast cancer are the most common form diagnosed in developed countries, making up approximately 75% of breast cancer cases in the US. TN breast cancer is another important subtype which makes up approximately 10% of the cases in the US.

GlobalData epidemiologists used age- and sex-specific diagnosed incidence and prevalence rates to forecast the diagnosed incident and prevalent cases, taking into account the significant relationship between age and HER2-negative incidence and prevalence. GlobalData epidemiologists applied country-specific incidence and prevalence rates of HER2-negative breast cancer, wherever available, to each country’s population to obtain the number of estimated diagnosed incident and prevalent cases.

The following data describes epidemiology of HER2-negative breast cancer cases. In 2018, the 8MM had 679,991 diagnosed incident cases of HER2-negative breast cancer. This is expected to increase to 788,999 diagnosed incident cases by 2028, at an Annual Growth Rate (AGR) of 1.60%. This increase is partly attributed to the moderately rising trend in incidence in the 8MM, combined with underlying demographic changes in the respective markets. The 8MM will also see an increase in five-year diagnosed prevalent cases of HER2- negative breast cancer throughout the forecast period at an AGR of 0.88%, with 2,642,622 cases in 2018 and 2,874,871 in 2028. The development of more effective therapies, particularly for elderly patients, would improve survival from HER2-negative breast cancer.

Scope

HER2-Negative Breast Cancer Epidemiology Report and Model provide an overview of the risk factors and global trends of all invasive breast Cancer in the eight major markets (8MM: US, France, Germany, Italy, Spain, UK, Japan, and Urban China).

This report also includes a 10-year epidemiological forecast for the following segmentations in ages 18 years and older across the 8MM: diagnosed incident cases of all invasive, HER2-/HR+, and HER2-/HR- triple negative (TN) breast cancer; diagnosed five –year and 10-year prevalent cases all invasive, HER2-/HR+, and TN breast cancer; and diagnosed incident cases of HER2-/HR+ and TN breast cancer by cancer staging (stage I –IV). Additionally, diagnosed incident cases of HER2-HR+ and TN breast cancer cases are further segmented by metastasis, and biomarker expression. HER2-/HR+ breast cancer cases are also segmented by menopausal status.

The HER2-Negative Breast Cancer Epidemiology Report and Model were written and developed by Masters- and PhD-level epidemiologists.

The Epidemiology Report is in-depth, high quality, transparent and market-driven, providing expert analysis of disease trends in the 8MM.

The Epidemiology Model is easy to navigate, interactive with dashboards, and epidemiology-based with transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over a 10-year forecast period using reputable sources.

Reasons to buy

The HER2-negative breast cancer Epidemiology series will allow you to:

Develop business strategies by understanding the trends shaping and driving the global HER2-negative breast cancer market.

Quantify patient populations in the global HER2-negative breast cancer market to improve product design, pricing, and launch plans.

Organize sales and marketing efforts by identifying the cancer stages that present the best opportunities for HER2-negative breast cancer therapeutics in each of the markets covered.

Understand magnitude HER2-negative breast cancer market by subtypes such as biomarkers and distant metastasis.

Table of Contents

1 Table of Contents

1.1 List of Tables

1.2 List of Figures

2 HER2-Negative Breast Cancer: Executive Summary

2.1 Related Reports

2.2 Upcoming Reports

3 Epidemiology

3.1 Disease Background

3.2 Risk Factors and Comorbidities

3.3 Global and Historical Trends

3.3.1 US

3.3.2 5EU

3.3.3 Japan

3.3.4 China (Urban)

3.4 Forecast Methodology

3.4.1 Sources

3.4.2 Sources Not Used – 5EU

3.4.3 Forecast Assumptions and Methods

3.5 Epidemiological Forecast for HER2-Negative Breast Cancer (2018–2028)

3.5.1 Diagnosed Incident Cases of All Invasive Breast Cancer

3.5.2 Age-Specific Diagnosed Incident Cases of All Invasive Breast Cancer

3.5.3 Diagnosed Incident Cases of HER2-/HR+ Breast Cancer

3.5.4 Diagnosed Incident Cases of TN Breast Cancer

3.5.5 Proportion of Diagnosed Incident cases of HER2-/HR+ Breast Cancer by Stages

3.5.6 Proportion of Diagnosed Incident cases of TN Breast Cancer by Stages

3.5.7 Diagnosed Incident Cases of HER2-/HR+ Breast Cancer by Menopausal Status

3.5.8 Diagnosed Incident cases of HER2-Negative Breast Cancer by PD-1 and PD-L1 Expression

3.5.9 Diagnosed Incident Cases of HER2-Negative Breast Cancer with BRCA Mutation

3.5.10 Diagnosed Incident Cases of HER2-Negative Breast Cancer with PI3KCA Mutation

3.5.11 Diagnosed Incident Cases of HER2-Negative Breast Cancer by Bone Metastasis

3.5.12 Diagnosed Incident Cases of HER2-Negative Breast Cancer with Brain/CNS Metastasis

3.5.13 Five-Year Diagnosed Prevalent Cases of All Invasive Breast Cancer

3.5.14 Five-Year Diagnosed Prevalent Cases of HER2-Negative Breast cancer

3.5.15 10-Year Diagnosed Prevalent Cases of All Invasive Breast Cancer

3.5.16 10-Year Diagnosed Prevalent Cases of HER2-Negative Breast cancer

3.6 Discussion

3.6.1 Epidemiological Forecast Insight

3.6.2 Limitations of Analysis

3.6.3 Strengths of Analysis

4 Appendix

4.1 Bibliography

4.2 About the Authors

4.2.1 Epidemiologist

4.2.2 Reviewers

4.2.3 Global Director of Therapy Analysis and Epidemiology

4.2.4 Global Head and EVP of Healthcare Operations and Strategy

4.3 About GlobalData

4.4 Contact Us

4.5 Disclaimer

List of Tables

Table 1: Risk Factors and Comorbidities for All Invasive Breast Cancer

List of Figures

Figure 1: 8MM, Diagnosed Incident Cases of HER2-Negative Breast Cancer, Women, Ages ≥18 Years, 2018 and 2028

Figure 2: 8MM, Diagnosed Incidence Rates of All Invasive Breast Cancer, Ages ≥18 Years, Women, Cases per 100,000 Population, 2008‒2028

Figure 3: Sources Used for Diagnosed Incident Cases of All Invasive Breast Cancer

Figure 4: Sources Used for Diagnosed Incident Cases of HER2-/HR+ and TN Breast Cancer

Figure 5 : Sources Used for Diagnosed Incident Cases of HER2-/HR+ and TN Breast Cancer by Stage

Figure 6: Sources Used for Diagnosed Prevalent Cases of All Invasive Breast Cancer

Figure 7 : Diagnosed Incident Cases of All Invasive Breast Cancer, 8MM, Women, Ages ≥18 Years, 2018

Figure 8: 8MM, Age-Specific Diagnosed Incident Cases of All Invasive Breast Cancer, Women, Ages ≥18 Years, N, 2018

Figure 9: Diagnosed Incident Cases of HER2-/HR+ Breast Cancer, 8MM, Women, Ages ≥18 Years, N, 2018

Figure 10: Diagnosed Incident Cases of TN Breast Cancer, 8MM, Women, Ages ≥18 Years, N, 2018

Figure 11: Proportion of Diagnosed Incident Cases of HER2-/HR+ Breast Cancer by Stage, 8MM, Women, Ages ≥18 Years, N, 2018

Figure 12: Proportion of Diagnosed Incident Cases of TN Breast Cancer by Stage, 8MM, Women, Ages ≥18 Years, 2018

Figure 13: Proportion of HER2-/HR+ Breast Cancer by Menopausal Status, 8MM, Women, Ages ≥18 Years, 2018

Figure 14: HER2-Negative Breast Cancer by PD-1 and PD-L1 Expression, 8MM, Women, Ages ≥18 Years, 2018

Figure 15: Diagnosed Incident Cases of HER2-Negative Breast Cancer with BRCA Mutation, 8MM, Women, Ages ≥18 Years, 2018

Figure 16: HER2-Negative Breast Cancer by PI3K and AKT Mutation, 8MM, Women, Ages ≥18 Years, 2018

Figure 17: Diagnosed Incident Cases of HER2-Negative Breast Cancer by Bone Metastasis, 8MM, Women, Ages ≥18 Years, 2018

Figure 18: Diagnosed Incident Cases of HER2-Negative Breast Cancer with Brain/CNS Metastasis, 8MM, Women, Ages ≥18 Years, 2018

Figure 19 : Five-Year Diagnosed Prevalent Cases of All Invasive Breast Cancer, 8MM, Women, Ages ≥18 Years, 2018

Figure 20 : Five-Year Diagnosed Prevalent Cases of HER2-Negative Breast Cancer, 8MM, Women, Ages ≥18 Years, N, 2018

Figure 21 : 10-Year Diagnosed Prevalent Cases of All Invasive Breast Cancer, 8MM, Women, Ages ≥18 Years, N, 2018

Figure 22 : 10-Year Diagnosed Prevalent Cases of HER2-Negative Breast Cancer, 8MM, Women, Ages ≥18 Years, N, 2018

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